Am I screwed for college?

I'm a senior and I'm a very good student. I'm ranked 6 out of 122. I'm the president of student council, the VP of National English Honor Society, and the Co-director of another club. I'm also in the NHS. I've always gotten 90s in school but this year has been a struggle. I got 500s on the SAT, a 3 on the AP US and I just took midterms and got a 46 on my calculus midterm (I hate that cl) even though I have an 80 in the cl. Are colleges going to see 90s and then that big ol' 46 and reject me if I applied to selective schools like Var? I'm freaking out over here!